Enkephalins, catecholamines, and psychological mood alterations: effects of prolonged exercise. P.A. Farrell A.B. Gustafson W.P. Morgan C.B. Pert Med Sci Sports Exerc August, 1987; 19(4):347-53 PMID: 0003657483; UI: 88013208
Visualization and characterization of interleukin 1 receptors in brain. W.L. Farrar P.L. Kilian M.R. Ruff J.M. Hill C.B Pert J Immunol July, 1987; 139(2):459-63 PMID: 0002955042; UI: 87252201
Visualization of cytokine and virus receptors common to the immune and central nervous system. W.L. Farrar P. Kilian J.M. Hill M.R. Ruff C.B. Pert Lymphokine Res January, 1987; 6(1):29-34 PMID: 0002950283; UI: 87143045
Neuropeptides and their receptors: a psychosomatic network. C.B. Pert M.R. Ruff R.J. Weber M. Herkenham J Immunol August, 1985; 135(2 Suppl):820s-826s PMID: 0002989371; UI: 85235646
Are there antibodies against brain in sera from schizophrenic patients? Review and prospectus. L.E. DeLisi R.J. Weber C.B. Pert Biol Psychiatry January, 1985; 20(1):110-5 No Abstract Available. PMID: 0003155486; UI: 85073061
A request for serum samples from psychiatric patients with associated autoimmune disease: is some psychosis caused by an autoimmune response to neurotransmitter receptors? [letter] C.B. Pert Commun Psychopharmacol ; 1(3):307-9 No Abstract Available. PMID: 0000023918; UI: 78106097
Vasoactive intestinal peptide receptors in rat spleen and brain: a shared communication network.
C.J. Wiedermann K. Sertl B. Zipser J.M. Hill C.B. Pert Peptides ; 9 Suppl 1():21-8
PMID: 0002856804; UI: 93268636
The psychosomatic network: foundations of mind-body medicine. C.B. Pert H.E. Dreher M.R. Ruff
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE Jul 1998; 4(4):30-41 Department of Physiology and Biophysics, Georgetown University Medical Center in Washington, DC, USA.
PMID: 0009656499 UI: 98320655
Research in the 1980s uncovered ubiquitous neuropeptide-receptor distribution in brain structures associated with emotional processing, and throughout many organ systems. This finding supported neuropeptides as biochemical substrates of emotion, and the neuropeptide-receptor network as a parasynaptic system crossing traditional brain-body boundaries.
The medical relevance of these findings was affirmed by psychoneuroimmunology research: neuropeptides help to regulate immunocyte trafficking, there is bidirectional communication between nervous and immune system components, immunocytes produce neuropeptides, and nerve cells produce immune-associated cytokines. In the past decade, the concept of a unified psychosomatic network has been strengthened by animal and human research demonstrating relationships between behavior and neuropeptide-mediated regulation of immune functions. Research on emotional expression or disclosure in healthy human subjects as well as in cancer and HIV-positive patients has shown significant positive correlations with clinically relevant immune functions and/or positive health outcomes. Psychosocial interventions emphasizing emotional expression or active coping have evidenced survival benefits in breast cancer and melanoma.
These findings suggest that emotional expression generates balance in the neuropeptide-receptor network and a functional healing system. Emotional expression is also a marker for psychospiritual vitalization, and further research should evaluate links between energy-based models of health and neuropeptide-receptor-based models under the rubric of an informational paradigm.